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50 In hippocampal I/R, it attenuated neuronal injury by modulating key regulatory genes —early growth response 1 (Egr1), AKT serine/threonine kinase 1 (Akt1), Kirsten rat sarcoma viral oncogene homolog (Kras), proto-oncogene tyrosine-protein kinase Src (Src), vascular endothelial growth factor receptor 2 (VEGFR2), nitric oxide synthase 3 (NOS3), and nitric oxide synthase 1 (NOS1)—and suppressing nitric oxide synthase 2 (NOS2) and NF-κB signaling, highlighting its ability to influence multiple ROS-related pathways