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Stratified Medicine for the Use of Antidiabetic Medication in Treatment of Type II Diabetes and Cancer: Where do We Go From Here
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Central to this interaction are HIF family members, which serve as key mediators: HIF-1α amplifies Wnt/β-catenin signaling in hypoxic environments by enhancing β-catenin activity and upregulating downstream targets such as LEF-1 and TCF-1 (Mazumdar et al., 2010)
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